منابع مشابه
Structure and function of SH2 domains.
In order for cells to respond to their environment, a series of regulated molecular events has to take place. External signalling molecules bind to cellular receptors and thereby trigger the activation of multiple intracellular pathways, which modify cellular phenotypes. The cell-surface receptors for a wide range of polypeptide hormones possess protein tyrosine kinase activity, which is induce...
متن کاملZIP codes for delivering SH2 domains
Around the year 1990, it was discovered that src-homol-ogy 2 (SH2) domains could bind to phosphotyrosine A number of proteins implicated in protein-tyrosine kinase signaling pathways were known to contain SH2 domains, and this discovery revealed how these proteins could form multimeric signaling complexes in response to activation of growth factor receptor family protein-Tyr kinases. However, t...
متن کاملSH2 domains: A question of independence
The three-dimensional structures of parts of two enzymes that contain tandem Src homology 2 (SH2) domains have recently been determined. The structures suggest how the SH2 domains function in concert to regulate enzymatic activity and localization.
متن کاملHigh-throughput phosphotyrosine profiling using SH2 domains.
Protein tyrosine phosphorylation controls many aspects of signaling in multicellular organisms. One of the major consequences of tyrosine phosphorylation is the creation of binding sites for proteins containing Src homology 2 (SH2) domains. To profile the global tyrosine phosphorylation state of the cell, we have developed proteomic binding assays encompassing nearly the full complement of huma...
متن کاملFolding of tandem-linked domains.
One of the factors, which influences protein folding in vivo, is a linkage of protein domains into multidomain tandems. However, relatively little is known about the impact of domain connectivity on protein folding mechanisms. In this article, we use coarse grained models of proteins to explore folding of tandem-linked domains (TLD). We found TLD folding to follow two scenarios. In the first, t...
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ژورنال
عنوان ژورنال: Nature
سال: 1995
ISSN: 0028-0836,1476-4687
DOI: 10.1038/377017a0